Describe the disagreement between the north and south that resulted in the Missouri compromise?

The disagreement that resulted in the Missouri compromise was that Missouri, part of the Louisiana Purchase, should be a slave state according to the South. The North thought that it should be free of slaves, so eventually, Henry Clay made it so that Missouri was a slave state, and Maine was a free state. That made it so that slavery was banned in the remainder of the Louisiana Territory north of the 36*30 parallel.