Can you observe Compton Effect if a proton is substituted in place of electron?

No, the Compton Effect specifically involves the scattering of photons by charged particles, and it is most commonly observed with electrons due to their relatively small mass and charge. Protons, being much more massive than electrons, would not exhibit the same behavior in photon interaction. The energy and momentum transfer in a photon-proton collision would be significantly different, making the classic Compton scattering scenario inapplicable.