If only the mother has the thalassemia trait, each child has a 50% chance of inheriting the trait and becoming a carrier, and a 50% chance of being unaffected. The father’s genotype will determine the overall risk for the children. If the father does not have thalassemia or the trait, the children will only be carriers. However, if the father also carries the trait, there is a possibility of having children with thalassemia disease.
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