How would the repeated sickling and unsickling of the cells affect the average life span of red blood cells?

Repeated sickling and unsickling of red blood cells, as seen in conditions like sickle cell disease, leads to increased cell damage and a higher rate of hemolysis. This mechanical stress shortens the lifespan of the affected red blood cells, which typically live around 120 days under normal conditions. In sickle cell disease, the average lifespan can drop to as low as 10 to 20 days. As a result, the body struggles to produce enough healthy red blood cells to maintain adequate oxygen transport.