Can a jc Higgins model 88 pistol shoot a 22lr bullet?

No, a JC Higgins Model 88 pistol is not designed to shoot .22 LR bullets. It is specifically chambered for .22 Short cartridges. Attempting to use .22 LR ammunition in a gun not designed for it can be dangerous and may cause damage to the firearm or result in injury. Always use the appropriate ammunition for your firearm.