Is it safe to take Cymbalta and Tylenol 3?

Yes it is safe to take all three medications together as long as they are taken as prescribed. The only significant drug interaction is between the Vistaril (hydroxyzine) and Lortab (hydrocodone/APAP). Both are sedating and can have a synergetic effect increasing the risk of CNS depression and psychomotor impairment. However, when the medications are used properly there is little risk.