If you are talking about the Black Death plague then people did nothing. They thought it was a punishment from God and they couldn't do anything to stop it. They didn't know that rats with infected fleas were spreading it. There were lots of rats, because in the Dark Ages, there were no toilets so people dumped their garbage in the streets. People also went months without changing clothes. It was dirty and that made it easier for people to get sick from the plague.
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