What setting on the Fender Mustang V is closest to Blink-182?

To achieve a sound closest to Blink-182 on the Fender Mustang V, try using the "Punk" preset, which emulates a high-gain tone with plenty of mid-range presence. Additionally, dial in some reverb and moderate delay to replicate the band's signature sound. Adjust the amp settings to emphasize treble and presence while keeping the bass and mid-range balanced. Experiment with the gain to reach the desired level of distortion typical of Tom DeLonge's guitar tone.