Yes, when Sarah saw Ishmael teasing Isaac, she asked Abraham to send Ishmael and his mother, Hagar, away. At first, Abraham did not want to, but God spoke to him, telling him to listen to Sarah's voice. This was the beginning of a fulfillment of a prophecy. Isaac would be the one through whom God's purpose would be fulfilled. The one through whom Messiah would come (Genesis 21:8-13)(Genesis 17:15-21/Genesis 25:5-9) who would provide a hope for ALL mankind, and benefit any who chose to accept it (Genesis 12:3/Galatians 3:14).
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