Can you take 325mg oxycodone and extra strength Tylenol?

From your question I assume you are referring to brand name Percocet or generic oxycodone with Tylenol?

The most prescribed strength for Percocet is 325mg Tylenol and 5mg oxycodone, the opposite of what you wrote.

If you do truly mean to ask if one can take 325mg oxycodone with Tylenol I highly recommend you take this question to your doctor before trying such a thing. In most instances, taking this much oxycodone would be fatal.