What city at the mouth of the Adriatic sea used its geographical position to become a major center of trade?

The city at the mouth of the Adriatic Sea that became a major center of trade is Venice. Its strategic location allowed it to serve as a crucial hub for commerce between Europe and the East, facilitating trade in spices, silk, and other goods. Venice's extensive canals and maritime prowess further enhanced its status as a powerful maritime republic during the Middle Ages and the Renaissance.