Can you take Zoloft and hydroxyzine together?

First, an important note: You should always discuss possible drug interactions with your physician.

Hydroxyzine is an antihistamine, and it can affect the action of some antibiotics (including doxyclcine) by causing your body to process the antibiotic more quickly. This can prevent the antibiotic from doing its job. You may need to take the doxyclcine for a longer period of time, or you may need to hold off on the hydroxyzine until you've successfully treated your infection.

With that said, if a doctor prescribes an antihistamine along with an antibiotic, you can safely take both medications. Make sure your physician knows about every drug you're taking when discussing treatments.