Can you paint rustoleum over latex?

Oh, absolutely! Painting Rust-Oleum over latex is possible, but you'll want to make sure the latex paint is fully cured and clean before applying the Rust-Oleum. Just remember to lightly sand the latex paint and apply a primer before painting with Rust-Oleum for the best results. Just like in painting, it's all about layering and taking your time to create something beautiful.