Can you get cdls after three DUIs in South Carolina?

So long as you've met the conditions for reinstatement of your licence, you can upgrade to a CDL. However, with three DUIs, you may want to consider other career options, unless your DUIs occurred a very long time ago. If any of them have occurred within the last three years, you're untouchable to any prospective employer. If any of them have occurred within the last ten years, it's still going to be an uphill battle to try finding someone who'll hire you. If you have multiple DUIs within the past ten years, you once again gain that 'untouchable' status.