In what ways were native Americans impacted by settlers moving west?

The settlement in the west affected the native Americans that lived there because once us Americans kept on pushing west after making Ohio a state we pushed into new areas .we settled in the territory of Indiana and other lands further west and the tide of settlement had a grave impact on native Americans like exposing them to disease's such as small pox,measles,and influenza killed thousands of them.and settlers took over a large part of there hunting grounds.took the forest for there farming. native Americans tradition,pover,home,life,and population declined.and that's how the settlement in the west affected the native Americans)