What is total annual expense of US Government?

As of the most recent data, the total annual expense of the U.S. government typically exceeds $6 trillion. This figure includes mandatory spending, discretionary spending, and interest on the national debt. The budget can vary each year based on economic conditions and legislative priorities. For the most accurate and current figures, it's advisable to consult the latest reports from the U.S. Office of Management and Budget or the Congressional Budget Office.