Depakote should not be taken in conjunction with Alcohol, which NyQuil does contain. However the amount of Alcohol in a single adult dosage of NyQuil should not cause harm. Plus you should be going directly to bed after taking the NyQuil dose. Any symptoms of dizziness, or vision difficulty, speech, etc should go un-noticed.
However, to be absolutely safe, ask your Doctor about your specific requirements!
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