Hi I've just been prescribed Tramadol (Tramset, which is a combination of 37,5mg Tramadol and 325mg Acetaminophen) for muscle pain, and Domperidone (10mg original) taken at the same time to prevent nausea and vomiting from Tramadol. (by a doctor in Japan)
The first time i took Tramadol on an empty stomach, and after having dinner, i got a terrible stomach ache, so i took one 10mg Domperidone as suggested.
My stomach ache and nausea got a lot better, but i must tell you this combinations makes you very sleepy :) I think after a couple of days we will get used to it.
To conclude, from my experience it is safe to take them together (although I'm still on low dose).
I hope you find my info useful :)
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