What is the value of a 1936 E Indian head nickel with an upside down buffalo on the back?

Well, darling, that upside-down buffalo on a 1936 E Indian head nickel might turn a few heads, but it doesn't necessarily mean it's worth a fortune. The value of a coin like that can vary depending on its condition, rarity, and demand from collectors. I'd suggest getting it appraised by a professional to get a more accurate idea of its worth.