Does hemoglobin genotype change from SS to AA after cord blood transplant?

Yes, after a cord blood transplant, a patient with the hemoglobin genotype SS (sickle cell disease) can potentially change to AA (normal hemoglobin) if the transplant is successful and the donor's hematopoietic stem cells engraft properly. The new stem cells from the cord blood will produce red blood cells with the genotype of the donor, which can lead to the production of normal hemoglobin. However, the outcome depends on factors such as donor compatibility, the patient's health, and the effectiveness of the transplant.