What is the quickest driving route from Portsmouth va to Birmingham ala?

The quickest driving route from Portsmouth, VA, to Birmingham, AL, typically involves taking I-64 W to I-81 S, then merging onto I-75 S toward Atlanta. From Atlanta, you'll take I-20 W directly to Birmingham. This route covers approximately 600 miles and usually takes around 9 to 10 hours, depending on traffic and road conditions. Always check a navigation app for real-time updates before your trip.