Is it safe to take 600 mg ibuprofen with 200 mg Tylenol?

These two medications work on pain through different mechanisms so they can be taken together, but DO NOT take them until you have talked to your doctor and/or pharmacist. These drugs may have reactions to other medications you are on, diseases, and/or food and drink.

p.s. the 325 mg in percocet refers to the acetaminophen, but it also contains oxycodone (narcotic).