What is the cell structure where glucose is broken down to make energy?

Glucose is broken down to make energy primarily in the mitochondria of cells. This process occurs through cellular respiration, which includes glycolysis in the cytoplasm, followed by the Krebs cycle and oxidative phosphorylation in the mitochondria. The mitochondria are often referred to as the "powerhouses" of the cell because they generate adenosine triphosphate (ATP), the energy currency of the cell, from the breakdown of glucose.