Did the calusas have any enemies?

Yes, the Calusa people, who inhabited the southwestern coast of Florida, had conflicts with neighboring tribes and European settlers. They were known to engage in warfare with groups such as the Timucua and other Indigenous tribes in the region. Additionally, the arrival of Spanish explorers and settlers in the 16th century led to further hostilities and competition for resources. The Calusa's resistance to colonization ultimately contributed to their decline.