Should you take methotrexate on an empty stomach or with food?

Methotrexate can be taken either with food or on an empty stomach, but taking it with food may help reduce gastrointestinal side effects such as nausea. It's essential to follow your healthcare provider's instructions regarding timing and food intake. Consistency in how you take the medication is also important for maintaining stable drug levels in your body. Always consult your doctor for personalized advice.