The best option is by train, as 6 - 8 trains typically operate per hour from the purpose built station located within the Airport terminal. The journey time typically takes between 18 - 25 minutes.
Also, buses from the Airport bus station operate very frequently and the journey usually takes just under an hour to reach Manchester Piccadilly bus station. The cost is around the same as the train, however if you're planning to make several journeys the same day with the operator an unlimited travel day ticket would be good value.
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