How do you program the door handle to open all four doors on a 2008 Lexus IS250?

To program the door handle to open all four doors on a 2008 Lexus IS250, first, ensure that the vehicle is in the "On" position but the engine is not running. Then, press and hold the unlock button on the key fob while simultaneously pressing the lock button three times. Release both buttons and the doors should now be programmed to unlock all at once when using the door handle or key fob. Always consult your owner’s manual for specific instructions or variations.