How do you address an invitation to a us senator and his wife?

When addressing an invitation to a U.S. senator and his wife, you should use the formal title "The Honorable" followed by the senator's full name. For example, you would write "The Honorable [First Name Last Name], United States Senator, and Mrs. [Last Name]." If you prefer a slightly less formal approach, you can simply use "Senator [Last Name] and Mrs. [Last Name]." Always ensure that the invitation is respectful and uses proper titles.