How many combination of 5 numbers are possible from 1 to 49?

To calculate the number of combinations of 5 numbers possible from 1 to 49, we use the combination formula, which is nCr = n! / (r!(n-r)!). In this case, n = 49 (total numbers) and r = 5 (numbers chosen). Plugging these values into the formula, we get 49C5 = 49! / (5!(49-5)!) = 1,906,884 combinations.