What old Cartoon Network anime movie invalid a girl a guy a talking wolf it had some conflict in it can't remember?

It sounds like you're describing "The Wolf's Rain," which, while not a movie but a series, features a group of wolves in a post-apocalyptic world, including a girl and a talking wolf. However, if you're thinking of a movie, it might be "The Cat Returns," which features a girl, a cat, and some fantastical elements but doesn't involve a wolf. If you meant "Kimba the White Lion," it also has a mix of conflicts involving animals. These shows often aired on Cartoon Network, which could be why they come to mind.