Is it possible to dissolve estrogens in water?

Estrogens are generally not soluble in water due to their lipophilic (fat-loving) nature, which means they tend to dissolve better in organic solvents or lipids. However, they can be made soluble in water through various methods, such as creating aqueous solutions with the help of surfactants or by using specific formulations that enhance their solubility. Nonetheless, in their natural state, estrogens are primarily hydrophobic and do not readily dissolve in water.