Can you take Diphenhydramine HCl and Advil together?

Tylenol is acetaminophen so it would not be advisable to take Tylenol and acetaminophen/diphenhydramine since it would be a double dose of acetaminophen. However, it also depends on the total dose of the acetaminophen. Typically, you should limit a single dose of acetaminophen to 1000mg and a maximum of 4000 mg per 24 hour period.