6.50 means that the tyre/tire is six and a half inches wide.
The 10 is the rim diameter in inches that it fits onto.
The 10pr stands for "ten ply rating" so the tire/tyre strength is equivalent to an old-time tyre that had ten actual plies of canvas in its construction. Nowadays steel and nylon are used as reinforcement and as far as I know canvas is no longer used. One problem with canvas or cloth reinforcement is that it eventually rots and the tyre bursts.
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