What are some disadvantages of anti federalism?

Anti-federalism can lead to a fragmented government structure, resulting in inconsistencies in laws and policies across different states. This decentralization may hinder effective national responses to issues like economic crises or public health emergencies. Additionally, it can diminish the strength and unity of the nation, making it harder to negotiate on the international stage. Lastly, anti-federalism often lacks a cohesive framework for protecting individual rights on a national level.