What battle was the most overwhelming slaughter ever achieved by american indians against the united states army?

The Battle of Wabash, often called Harmer's Defeat was the most overwhelming slaughter ever achieved by American Indians against the US Army. General Harmer gathered together 1,460 regulars and militia with the goal of attacking the Miami tribe at what is now Fort Wayne, Indiana. The Miami got Word of the attack, and fled carrying as many supplies as possible. General Harmer sent out scouts who ran across an Indian on horseback. The Indian, who was a decoy, fled down a small path. Harmer summoned his men, and were led to a marshy area where they could neither pursue or retreat easily. The 100 Miami slaughtered most of the militia.