What study is linked directly with the National Research Act of 1974?

The National Research Act of 1974 is directly linked to the Tuskegee Syphilis Study, which began in the 1930s and continued until the early 1970s. This unethical study involved the observation of untreated syphilis in African American men without their informed consent, even after effective treatment became available. The outrage over the study's ethical violations led to the Act's passage, which established regulations to protect human subjects in research and created the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research.