What are some recommended activities to do during a layover in Guadalajara?

During a layover in Guadalajara, some recommended activities include visiting the historic city center to see landmarks like the Cathedral and Hospicio Cabaas, exploring the artsy neighborhood of Tlaquepaque for shopping and dining, and sampling traditional Mexican cuisine at local markets or restaurants. Additionally, you can visit the Tequila region for a tour of a distillery or take a day trip to the nearby town of Tequila.