In combination with alcohol barbiturates have the potential for severe impairment?

Yes. They have what is called an additive effect. Meaning that drinking alcohol with an opiate makes both have a stronger effect.

Mixing opiates with alcohol is dangerous because it changes the way your body reacts to the medication. Some of the dangers of mixing opiates with alcohol include:

1.Respiratory problems, including the inability to breathe

2. Shallow breathing

3. Sleepiness

4. Increased risk of overdose

5. Confusion

6. Inability to remember how much medication you took

7. Increased tolerance