Can you take Ibuprofen with trimethoprim?

You can take it, but it's best to space out the doses. If you take them at the same time, the abrasiveness to the stomach can be too much.

In most cases you will get heartburn of some sort--you CAN'T take any antacids. Also, don't lay down for about an hour, as the doxycycline will dissolve in your throat and you will have way more problems than just an infection or heartburn!

http://www.ehow.com/how_2165217_avoid-doxycycline-side-effects.html