Does altitude affect polycythemia vera

Yes, altitude can affect polycythemia vera (PV). At higher altitudes, the reduced oxygen levels can stimulate the body to produce more red blood cells, potentially exacerbating the condition in individuals already predisposed to PV. However, the primary cause of PV is a mutation in the JAK2 gene, leading to increased red blood cell production regardless of altitude. It's important for patients with PV to monitor their condition and consult healthcare providers when considering travel to high-altitude locations.