Most muscles work in pairs, known as antagonistic pairs, where one muscle contracts while the other relaxes. However, some muscles, like the diaphragm, function independently to facilitate breathing without a direct opposing muscle. Additionally, certain muscles in the eye, such as the lateral and medial rectus, can also work in a more coordinated manner rather than strictly in pairs. Overall, while the majority of skeletal muscles operate in pairs, there are exceptions based on their specific functions.
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