What regulates discharge of CHYME into Duodenum?

The discharge of chyme from the stomach into the duodenum is primarily regulated by the pyloric sphincter, which controls the passage of partially digested food. Hormonal signals, particularly the release of secretin and cholecystokinin (CCK) in response to the presence of acidic chyme and fats in the duodenum, also play a crucial role. These hormones help modulate gastric emptying and stimulate the secretion of bile and pancreatic enzymes, ensuring optimal digestion in the small intestine.