Does a lizard bite hurt

This depends on the species and size of the animal in question, and your personal pain tolerance. Traditionally reptiles by body weight have a very high bite force when closing their jaw, but weak muscles for opening the mouth. For example my bearded dragon while fairly large doesn't really hurt if it bites. It may draw a pinch of blood but nothing crazy. Meanwhile my far far smaller Tokay gecko can quite literally bite your finger clean off if it gets a joint. There are also some other factors involved in reptile bites. Several species (mostly tropical&desert) carry vast quantities of diseases in their saliva. So while the bite may only hurt briefly, the diseases caused by the bite can be life threatening.