How much weight can a five axle tractor trailer carry?

For interstate travel in the US without requiring oversize permits, the gross weight is 80,000 lbs. What that translates to in cargo weight depends on the vehicle's tare (empty) weight. Typically, a truck with a flatbed trailer will be good for 45,000 - 48,000 lbs., and a truck pulling a dry box can typically haul 43,000 - 45,000 lbs. of freight.