Nothing stays in your body for more than 48 hours (nothing taken by mouth, drugs are a different story). So, give water 2-3 days for the ultimate water cleanse. Water won't do as good a job cleansing everything as a good cleansing vitamin. There are all sorts of detox systems sold at health food stores, you will notice a difference.
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Answer Depends on what you want to cleanse it of. If it is Marijuana, the THC sticks to your fat cells, so there is no way to clean it with water.
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Most water soluble substances have a half-life of less than a day - six hours is common. Half-life is the length of time it takes for half of what was there initially to be gone. As the amount remaining decreases, there is less driving force to remove the rest so the rate that it is excreted declines. At some point the amount remaining is so small that it is considered "gone" even if a little bit actually remains.
It also depends on whether the substance is taken into the cells or metabolized. Consuming water has little effect on flushing fat soluble substances from your system so you really don't cleanse them with water. Heavy metals also tend to stick around for a long time and are best removed by chelating with some chemical that can react with them to form a molecule that is more easily excreted. For substances that are metabolized, consuming water helps flush out the metabolites and thus slightly increases the driving force to metabolize what's left.
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