When can great dane dogs have puppies and why not?

Great Danes can typically have puppies after they reach sexual maturity, which is usually between 6 to 12 months of age. However, it's generally recommended to wait until they are at least 2 years old to ensure they are physically and mentally mature enough for breeding. Breeding too early can lead to health complications for both the mother and the puppies, including increased risk of developmental issues and difficulties during delivery due to the dog's size. Responsible breeding practices prioritize the health and well-being of both the mother and her offspring.