How does fibrosis affect compliance?

Fibrosis leads to the thickening and stiffening of tissues, which decreases the compliance of affected organs, such as the lungs or heart. This reduced compliance means that the organ cannot expand or contract as easily, resulting in impaired function. In the lungs, for instance, fibrosis can hinder effective gas exchange, while in the heart, it can affect the heart's ability to fill with blood properly. Overall, fibrosis disrupts normal physiological dynamics and can lead to significant health issues.