Can doctors tell the difference between methadone and oxycodone in urine sample?

No. Absolutely not. They are both oxycodone. Oxycontin is just a longer acting formulation.

Yes they can. The tests at my doctors can definitely tell the difference. one will show up has Oxycontin and the other will show as oxycodone. Now they have tests to make sure patients are using the drugs prescribed. Depending on the test the dr. uses it will tell this difference