Is it safe to use melatonin and oxycodone together?

Using melatonin and oxycodone together can pose risks, primarily due to the potential for increased sedation and respiratory depression. While melatonin is generally considered safe for short-term use, combining it with opioids like oxycodone may enhance drowsiness or impair cognitive function. It's essential to consult a healthcare professional before using these substances together to ensure safety and appropriate dosing.