How do you treat a popped blister the size of a quarter?

To treat a popped blister the size of a quarter, first gently clean the area with mild soap and water to prevent infection. Apply an antibiotic ointment to the exposed skin and cover it with a sterile, non-stick bandage or gauze to protect it. Change the dressing daily and keep an eye on the blister for any signs of infection, such as increased redness, swelling, or pus. Avoid further irritation and allow the area to heal naturally.